التراكم الحيوي والسمية لجسيمات ثاني أكسيد التيتانيوم النانوية بعد تناول الفئران الذكور عن طريق الفم

الملخص

Titanium dioxide nanoparticles (TiO2 NPs) are considered one of the top five nanoparticles used in consumer products. In the present study, male albino mice were used to estimate the effect of (TiO2), us-ing two doses (150, 600) mg/kg. The groups were divided according to the time of exposure (one, fourteen, thirty day), control. The re-sult showed significant increase (p <= 0.05) in White Blood Cell (W.B.C); Mean Cell Volume (MCV); Mean Cell Haemoglobin Concentration (MCHC), Mean Cell Haemoglobin (MCH) and Platelets (PLT), and a significant decrease in Red Blood Cell (R.B.C.) and Haemoglobin (Hb) after thirty day of exposure. However biochemical parameters in-clude AST peak highest mean value after fourteen day of exposure to the dose (600 mg/kg), while ALT and ALP significantly increased and decreased, respectively. Creatinine and uric acid rose sharply while urea, cholesterol, HDL and LDL decreased. Intra-gastric exposure caused high accumulation in kidney, spleen and liver respectively. In general the doses used caused histological alteration, such as con-gested dilated portal tract with heavy inflammatory cells infiltration and dilated central venule and glomerular congestion, tubular con-gestion, atrophy, chronic inflammatory cells infiltration and dilated tubules with flat atrophied lining epithelium of kidney. It is an indica-tion of the different degree of organ injury due to the toxicity of NPs.