Vanadyl sulfate and Lycopene in prevention of Ethanol induced gastric ulcer

Abstract

Background:
gastric ulcer is a state resulted from imbalance between the erosive action of acid and pepsin & mucosal defense mechanism in the stomach and may be correlated with antioxidant agents.
Materials and methods:
thirty five healthy albino male rats weighing 200-220 grams were involved in this study. The animals were allocated to five groups. Each group was given orally one of the following agents: Lansoprazole, Vanadyl sulfate, lycopene and distilled water control. After five days of treatment ethanol 95% was used orally after one hour of the last dose. The animals were sacrificed one hour later, the ulcer preventive index and free radicales and serum electrolytes were estimated. Results:
high concentration of ethanol was found to produce a ratio of 100% ulceration in the stomach when administration done orally. The preventative index of both Vanadyl sulfate, lycopene was highly significant when compared to drug control (lansoprazole). All the tested agents produced highly significant changes in free radicals of the gastric tissue increasing GSH and decreasing MDA levels. Serum electrolytes (Na", K and Ca") were significantly changed by these agents.
Conclusion:
Vanadyl sulfate and Lycopene proved to have preventive effect against ethanol induced gastric ulcer and the possibility to be used after clinical trials for patients with gastric ulcers.