The Use of Diane – 35 in The Treatment of Infertility

Abstract

Diane-35 is a hormonal compound of progesterone & oestrogen (with anti-androgen effect) used for the treatment of androgenic symptoms in females like severe cases of seborrhea & hirsuitism, it can also be used for cases of infertility.
A case control study was performed about the use of diane-35 in the treatment of infertility in women with polycystic ovarian syndrome, the study included 589
infertile ladies with polycystic ovary they were chosen among 3091 infertile ladies for other different causes attending Al-Diwaniyah maternity hospital & a private clinic in Samawa city from June 2009 until June 2011
372 women were treated with diane-35plus induction of ovulation (inductionwithclomiphene + Gonal F) while 217 women were treated with 1 1 induction alone duration of treatment was 3-6 months according to patient response, the results showed that 220 out of 589 became pregnant while 369 did not among those 220 pregnant ladies 186 were those treated with diane-35 plus ovulation induction while 34 were those treated with ovulation induction alone this means that about 50% of ladies treated with diane-35 plus induction became pregnant while only 14%
of ladies treated with only ovulation induction became pregnant. We recommend that treatment modalities should be discussed with the patients including the success rates, cost, side effects also cases of infertile polycystic ovaries that don"t respond to ovulation induction alone are better treated with diane-35 plus ovulation induction..