Synthesis, Characterization, and Biological Activity Evaluation of Chalcones and Pyrazole Derivatives Derived from Indole

Abstract

This work ten compounds were prepared including chalcones derivatives (Z1-Z5) are made by reacting Benzaldehyde substitutes with indole in methanol solvent. Then the preparation of pyrazole derivatives (Z6-Z10) from the reaction of chalcone derivatives (Z1-Z5) with aqueous hydrazine in ethanol solvent. Characterization by using spectroscopic techniques Uv-vis, FT-IR, 1H-NMR, 13C-NMR of some the prepared compounds using DMSO-d6 a solvent. Antibacterial behaviors were investigated against a variety of bacteria, including E. coli Gram (-) ve, and S. aureus Gram (+) ve.