Labeling Study of Hydroxyethyl Starch with Tc99m And Investigation of The Biokinetic Behavior In Experimental Animals

دراسة تعليم مادة هيدروكسيد اثيل النشا بالتكنيشيوم 99 م وسلوكة البايلوجي في الحيوانات المختبرية

Abstract

The labeling of stannous hydroxyethyl starch (Sn-HES) with technetium-99m (Tc99m) has been studied.It was found that the formation of Tc99m-HES complex increased with raising of the pH, reaching a yield of over 90% at pH 6.5. Further experiments at pH 6.5 showed that the amount of reducing agent (SnCl2.2H2O) and the ligand (HES) has a little effect on the labeling yield of the complex.The organ distribution in mice has shown that Tc99mHES complex was cleared from the blood with relatively high accumulated in the liver and were no uptake of radiotracer in the lung, spleen and stomach. This work demonstrates the conditions that are necessary for the labeling of HES with Tc99m and its evaluation in experimental animals.