Allium sativum, Nigella sativum, Caryophyllus dianthus and Punicagranatum in improvementof salmonellosis in experimental rabbit model

الثوم , الحبة السوداء, القرنفل وحب الرمان في تحسين النموذج التجريبي لمرض التيفوئيد في الارانب

Abstract

The activity of medicinal plants against induced salmonellosis in rabbit was determined in vitro by Kirby-Baur , minimal inhibitory concentration (MIC) method . the results revealed that all the aqueous extract of the tested medicinal plants at a stock concentration of 2000 ng/ml had antisalmonella effect except Dianthus caryophyllus. Nigella sativum extract had the most potent effect with MIC (125 ng/ml)& both Allium sativum & punica granatum had MIC (250 ng/ml). In the mean time, a significant potentiation was obtained by double combination of chloramphenicol with Allium sativum or Punic granatum , MIC (31.25 ng/ml) or with Nigella sativum MIC (15.62 ng /ml). In conclusion both Allium sativum & Nigella sativum had shown antisalmonella activity when used singly or in combination with antibiotics.