Evaluation of some trace elements in type 2 diabetes mellitus patients

تقدير مستويات بعض العناصر النزرة لدى مرضى السكريII

Abstract

Noninsulin dependent diabetes mellitus is supposed to be associated with fluctuations in the
plasma levels of several trace elements. There is accumulating evidence that the metabolism of
several trace elements is altered in patients with noninsulin dependent diabetes mellitus and that
these nutrients might have specific roles in the pathogenesis and progression of this disorder.
Aim The aim of the present study is to compare the levels of essential trace elements including
copper (Cu), zinc (Zn), magnesium (Mg), iron (Fe), and calcium (ca) in type 2 diabetic patients ,
healthy controls . and their possible association with age, sex and glycemic status. Materials
and methods The comparative study included 100 type 2 diabetic patients and 30 as healthy
control. Blood samples of all the subjects were collected after an overnight fasting for the
determination of blood glucose, magnesium, zinc, copper, iron and calcium. Fasting blood sugar
(FBS) was determined by enzymatic colorimetric assay to confirm the status of the patients and
the controls while metals’ concentrations were measured with Atomic Absorption
Spectrophotometer. Results The mean values of serum Mg and Zn levels were significantly
reduced in blood samples of diabetic patients as compared to control subjects (p<0.01).The
serum Cu , Fe and Ca were significantly higher in blood samples of diabetic patients compared
to normal subject (p<0.01). Sex and age did not affect the trace elements concentration except
Cu showed a statistically significant increase with age. Glycemic status effect the trace elements
concentrations significantly. Conclusion The results confirm that alteration of some essential
trace metals are associated with diabetes mellitus.

هناك ارتباط مفترض بين داء السكري غير المعتمد على الانسولين (داء السكري II ) وبين تقلبات مستوى عدة عناصر نزرة في بلازما دم المرضى المصابين بهذا الداء. هناك تراكم لشواهد تدل على ﺇن استقلاب عدة عناصر نزرة يُغيََّر في مرضى داء السكري II وﺇن لهذه المغذيات دور محتمل و محدد في نشوء المرض و تطوره اللاحق